Fig. 5

In vivo biodistribution and anti-tumour effects of TP-GQDss/Enz. a Fluorescent image of mice obtained at 2, 4, 8, 24 h after administration of DIR, GQDss/DIR and TP-GQDss/DIR (yellow circle: tumour site); b Fluorescent image of tumour and chief organs sacrificed from mice at 24 h after administration; c, d body weight variations and tumour growth curves of mice, mean ± SD (n = 6), *p < 0.05, vs PBS; e Survival curves of mice, log-rank analysis, mean ± SD (n = 6), *p < 0.05, **p < 0.01, ***p < 0.001; f Representative HE staining images of heart, liver, spleen, lung, kidney, tumour of each group (400×)