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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Effect of the cagW-based gene vaccine on the immunologic properties of BALB/c mouse: an efficient candidate for Helicobacter pylori DNA vaccine

Fig. 7

Humoral immune responses induced by plasmids. Mice were immunized with pcDNA3.1 (+)-cagW-CS-NPs and pcDNA3.1 (+)-cagW, and were boosted once with a 3-week interval with PBS used as a control. Serum samples were collected from mice’s tail veins at indicated time points, and the titers of the IgG (a) and IgM (b) antibodies were detected by indirect ELISA assay. Data showed mean ± SD of OD at 490 nm. *p < 0.05 and **p < 0.01 (determined by one-way ANOVA followed by a Tukey–Kramer post hoc test)

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