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Fig. 8 | Journal of Nanobiotechnology

Fig. 8

From: M2 Macrophagy-derived exosomal miRNA-5106 induces bone mesenchymal stem cells towards osteoblastic fate by targeting salt-inducible kinase 2 and 3

Fig. 8

Schematic diagram showing proposed mechanisms by which exosomal miR-5106 derived from M2 macrophages induce the BMSCs towards osteoblastic differentiation. Enriched level of miR-5106 in MED-Exos enhances the inhibitory effect on SIK2 and SIK3. Decreased SIK2 and SIK3 expression induces BMSCs differentiation and thereby accelerates bone remodeling

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