Fig. 1

a Photograph of the integrated automatic cell negative depletion equipment for tumor cell pre-purification. The left side shows a multiway valve, and the right side depicts the wedge-shaped microfluidic chip. The three bottles with different colors are sample bottles for the cell sample, PBS and IMPs, respectively. b Characterization of the microfluidic chip by microspheres with different sizes. c Photograph of 30 μm microparticles in the first line. d Photograph of 20 μm microparticles in the second line. (3) Photograph of 10 μm microparticles in the third line