Fig. 4
From: Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6
UBE2O is the hub gene on saliva-Exos upregulated genes. a Valcano plot illustrating the differential mRNA expression level between saliva and saliva-Exos. The negative Log10 p values (y axis) are plotted against the Log2 fold changes in expression (x axis). b–e Analysis of biological process (BP) (b), cellular Component (CC) (c), molecular function (MF) (d) and KEGG pathway (e) of upregulated genes, the bubble diagram generated using the ggplot2 tool of the R software showing the top ten pathways. (f) Identification of UBE2O as one of the main hub genes using the DMNC algorithm to screen the upregulated genes. (g) UBE2O mRNA level in saliva and saliva-Exos assessed by qRT-PCR. n = 5. h, i UBE2O expression in HUVECs treated with PBS (control), saliva, and saliva-Exos, detected by Western blotting and qRT-PCR. ***p < 0.001, ****p < 0.0001