Skip to main content
Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6

Fig. 5

UBE2O promotes HUVEC function in vitro. a The UBE2O mRNA level was assessed by qRT-PCR after HUVECs were incubated with indicated treatments. b, c Proliferation of HUVECs after treatment with PBS, saliva, and saliva-Exos, measured by the CCK8 and EdU assays. d Distribution of HUVECs in the cell cycle assessed by flow cytometry. e–g Expression of cell cycle-related proteins determined by Western blotting. Evaluation of the migration of HUVECs by wound scratch assay and transwell assay. h Representative images of the tube formation assay in HUVECs treated with PBS, UBE2O, siUBE2O, and the combination of saliva-Exos and siUBE2O. i, j Quantitative analysis of total branch length and total number of branching points. *p < 0.05, **p < 0.01, ***p < 0.001

Back to article page