Fig. 1

a Schematic interpretation of T807/RPCNP-CUR in vivo. According to the precise targeting of T807, the novel biomimetic engineered delivery nanosystems accumulate in neurons after crossing the BBB. b The preparation of T807/RPCNP-CUR. First, the RBCm was derived from RBCs and bare NPs were prepared using an emulsification ultrasonication method. Next, the resulting RBC membranes were coated onto the surface of bare NPs through mechanical extrusion to form RPCNP-CUR. Finally, DSPE-PEG₃₄₀₀-T807 was inserted into the outer monolayer of RBCm to form T807/RPCNP-CUR NPs