| Day 1 (24 h) | Day 2 (48 h) | ||||||
---|---|---|---|---|---|---|---|---|
Drug | Median | Minimum | Maximum | P-value | Median | Minimum | Maximum | P-value |
D 25 µg | 61.27 | 54.61 | 74.21 | Standard | 72.31 | 72.06 | 78.35 | Standard |
ND 0.5 mg | − 5.29 | − 23.53 | 20.03 | 0.002 | 29.35 | 28.23 | 36.50 | 0.10 |
ND 1.0 mg | 0.89 | − 16.86 | 35.27 | 0.002 | 33.57 | 20.87 | 34.67 | 0.10 |
ND 1.5 mg | 23.30 | − 7.25 | 32.98 | 0.002 | 40.65 | 36.19 | 47.74 | 0.10 |
ND 2.0Â mg | 26.88 | 14.00 | 45.55 | 0.002 | 54.81 | 33.79 | 63.50 | 0.10 |
ND 2.5Â mg | 73.93 | 67.01 | 78.56 | 0.026 | 72.91 | 45.81 | 80.05 | 1.00 |
ND 3.0Â mg | 73.92 | 68.80 | 78.36 | 0.015 | 82.22 | 81.16 | 83.29 | 0.20 |