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Table 2 Median, minimum, maximum and P-values of comparison between free AcNDGA and PPDNS (drug-loaded polymeric nanospheres) at different concentrations from ANOVA statistical analysis using SPSS v.16

From: Facile synthesis and nanoscale features of a nanostructured nordihydroguaiaretic acid analog for therapeutic applications

 

Day 1 (24 h)

Day 2 (48 h)

Drug

Median

Minimum

Maximum

P-value

Median

Minimum

Maximum

P-value

D 25 µg

61.27

54.61

74.21

Standard

72.31

72.06

78.35

Standard

ND 0.5 mg

− 5.29

− 23.53

20.03

0.002

29.35

28.23

36.50

0.10

ND 1.0 mg

0.89

− 16.86

35.27

0.002

33.57

20.87

34.67

0.10

ND 1.5 mg

23.30

− 7.25

32.98

0.002

40.65

36.19

47.74

0.10

ND 2.0 mg

26.88

14.00

45.55

0.002

54.81

33.79

63.50

0.10

ND 2.5 mg

73.93

67.01

78.56

0.026

72.91

45.81

80.05

1.00

ND 3.0 mg

73.92

68.80

78.36

0.015

82.22

81.16

83.29

0.20

  1. D-Free AcNDGA; ND-PPDNS. Drug load of PPDNS (ND) = 10 µg drug per mg nanospheres
  2. P-value less than 0.05 is considered as statistically significant
  3. Day 1 P-values were *p ≤ 0.05. Day 2 P-values were not significant (N.S.)