Engineering nanoparticles to reprogram radiotherapy and immunotherapy: recent advances and future challenges

Table 2 Nanoparticle immunomodulation information and related cytokines

Nanoparticles	Immune checkpoint inhibitor	Anti-tumor immune activation	Cytokines secretion	References
Zeb-aPD1-NPs-Gel	Encapsulated aPD1	CD8⁺/CD4⁺ T cells	Unknown	[117]
DNIP	Co-encapsulated aPD1 and aOX40	CD8⁺ T cells	IFN-γ	[123]
Co-CHL	Encapsulated si-PDL1	CD8⁺ T cells	IFN-γ, IL-2	[130]
LPP-P4-Ep	Encapsulated si-PDL1	T cells	IFN-γ, IL-4, IL-6, IL-10	[137]
HA-Psi-DOX	Combine with aPD1	CD8⁺ /CD4⁺ T cells	IFN-γ, TNF-α	[143]
DMONs	Combine with aPDL1	CTLs	IFN-γ, TNF-α,IL-12, IL-1β	[149]
LCP NPs deliver MUC1 mRNA vaccine	Combine with CTLA-4	CD8⁺ T cells	IFN-γ	[154]

ISSN: 1477-3155