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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: MicroRNA-421-3p-abundant small extracellular vesicles derived from M2 bone marrow-derived macrophages attenuate apoptosis and promote motor function recovery via inhibition of mTOR in spinal cord injury

Fig. 3

M2 BMDM-sEVs attenuate tissue damage after SCI and improve motor function recovery. a Basso Mouse Scale Scoring at different times after spinal cord injury. b Representative footprints of animal walking 28 days post SCI. Blue: front paw print; red: hind paw print. c TUNEL staining (red) to detect the apoptotic cells in spinal cord, nuclei were counterstained with DAPI (blue). Scale bar: 100 µm. d Quantification of TUNEL-positive cells in each group. e Western blot analysis of apoptosis-related proteins in spinal cord. f Relative expression levels of apoptosis-related proteins normalized to GAPDH (*p < 0.05, ***p < 0.001)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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