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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Farnesal-loaded pH-sensitive polymeric micelles provided effective prevention and treatment on dental caries

Fig. 7

Treatments effects on the development of dental caries in rats. Animals were treated with distilled water, 15% ethanol, farnesol, farnesal, chlorhexidine, blank PMs, Far-PMs and PPi-Far-PMs, respectively. a The smooth-surface and sulcal-surface caries of molars were observed under a stereomicroscope (×14). The white arrow indicated the smooth-surface caries while the green arrow indicating the sulcal-surface caries. Quantitative assessment was based on carious lesion severity of smooth-surface and sulcal-surface according to the Keyes’ scoring system, including b the smooth-surface with enamel affected (Smo-E), c sulcal-surface with enamel affected (Sul-E), d sulcal-surface with dentin exposed (Sul-Ds), e sulcal-surface with 3/4 of the dentin affected (Sul-Dm). Values are expressed as mean ± standard deviation (n = 7). The Tamhane’s T2 test (*P < 0.05, **P < 0.01, ****P < 0.0001) was used to assess the treatment efficacy. Symbols represented statistical significance of the labeled groups relative to the group treated with distilled water (#P < 0.05, ##P < 0.01, ###P < 0.001, ####P < 0.0001). The caries reduction rate was determined as described in Methods

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