Fig. 7

p62 accumulation mediated inflammation through NF-κB activation. a BEAS-2b cells were treated with SiNPs at indicated concentrations for 12 h, followed by the cellular NF-κB as well as p-NF-κB protein expression detection by Western blot. b BEAS-2b cells were treated with SiNPs at 50 μg/mL for 12 h, then NF-κB expressions in nucleus or cytoplasm were detected by western blot. c BEAS-2b cells transfected with siRNA targeting p62 or control sequence were treated with or without SiNPs at 50 μg/mL for 12 h, followed by detection of p62, NF-κB as well as p-NF-κB protein expression. Quantification shown right represents the relative p-NFκB/NFκB expression level. All quantitative data are presented as mean ± SEM. **p < 0.01