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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Functional oral nanoparticles for delivering silibinin and cryptotanshinone against breast cancer lung metastasis

Fig. 3

a Cellular uptake of LPNs and W-LPNs in a Caco-2/HT29-MTX-E12 co-culture with or without mucus treatment with N-acetyl-l-cysteine. b Quantities of coumarin-6 absorbed per milligram cellular protein in Caco-2 cells treated with WGA-LPNs after co-incubation with mucin at various concentrations. c Confocal microscopy images of Caco-2 cells treated with FITC-labeled mucins and WGA-LPNs after incubation with FITC-labeled mucins. Rows 1–4 show the DAPI channel, fluorescein isothiocyanate (FITC) channel, tetramethylrhodamine isothiocyanate (TRITC) channel, and merged images, respectively. d  % uptake of WGA-LPNs or WGA-LPN-mucins by Caco-2 cells vs control in the presence of different inhibitors (mean ± SD, n = 5). *P < 0.05, **P < 0.01, ***P < 0.001

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