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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Three-dimensional culture and clinical drug responses of a highly metastatic human ovarian cancer HO-8910PM cells in nanofibrous microenvironments of three hydrogel biomaterials

Fig. 2

HO-8910PM cell viability and cell proliferation in 3D cell cultures. HO-8910PM cells were encapsulated in RADA16-I hydrogel, Matrigel and collagen I and cultivated for 1 day (a), 3 days (b), and 6 days (c), respectively. Gel-cell clumps were successfully harvested when 3D cell cultures were over at the desired time points. The photomicrographs were taken by phase contrast microscopy (top panels in a–c). The green fluorescent calcein-AM staining for the living cells was performed to indicate cell viability and robust cell proliferation with distinct cell shapes in all hydrogel volume (bottom panels in a–c)

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