Fig. 5

Therapeutic effect of DPLGA@[RAW-4T1] NPs on lung metastatic breast cancer. a Representative images of visualized metastatic nodules in the lungs (yellow circles) in each group. b Quantitative analysis of pulmonary metastatic nodules in breast cancer in each group. c Histological investigation of lung metastasis of breast cancer from each group measured by H&E staining. Scale bar = 200 μm. d Weight change in mice during treatment. Data are expressed as the mean ± SD (n = 5). e Typical images of H&E staining of heart tissues. Scale bar = 100 μm f Mean survival period of mice with 4T1 tumors in different treatment groups. *p < 0.05, **p < 0.01