Fig. 4

In vivo fluorescence imaging characteristics of nude mice bearing PC-3 tumours after orbital vein injection of ICG and ICG-PTX NBs. a Near-infrared fluorescence images of tumour-bearing nude mice. b NIR fluorescence images of major organs and tumours 2 h post-injection of ICG and ICG-PTX NBs. c Time-fluorescence intensity curve in the tumour region at different time points, the data are shown as mean ± SD (n = 3). d Semiquantitative biodistribution of ICG and ICG-PTX NBs in nude mice determined by the averaged fluorescence intensity of each organ. The data are shown as the mean ± SD (n = 3), *P < 0.05, **P < 0.01