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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Intra-articular delivery of celastrol by hollow mesoporous silica nanoparticles for pH-sensitive anti-inflammatory therapy against knee osteoarthritis

Fig. 7

Paw withdrawal threshold (PWT) of MIA-induced OA rats treated with CSL, HMSNs, HMSNs-Cs and CSL@HMSNs-CS (CHC). CSL@HMSNs-CS significantly upper the PWT of OA rats. (**, comparison with saline group, p < 0.01; ▲, comparison between the groups treated with simple CSL and CSL@HMSNs-CS (CHC), p < 0.05; ▲▲, comparison between the groups treated with simple CSL and CSL@HMSNs-CS (CHC), p < 0.01)

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