Fig. 8From: Intra-articular delivery of celastrol by hollow mesoporous silica nanoparticles for pH-sensitive anti-inflammatory therapy against knee osteoarthritisA MRI images of the knee joints. (a) saline; (b) OA; (c) CSL; (d)HMSNs; (e) HMSNs-Cs; (f) CSL@HMSNs-CS (CHC). Articular surface erosion was marked by arrow and prominent joint effusion was marked by star. B Safranin O Fast Green staining. (a) saline; (b) OA; (c) CSL; (d)HMSNs; (e) HMSNs-Cs; (f) CSL@HMSNs-CS (CHC). The proteoglycan in cartilage martrix stains red and the collagenous fiber in bone stains blue or green. C Cartilage damage was measured on Safranin-O Fast Green staining histological slides by a modified OARSI score system (n = 5)Back to article page