Fig. 8
hNET-homing nanovehicles are highly biocompatible. a Premature release kinetics of Elli from FRT nanovehicles over 72 h in Ringer’s solution. b Polyacrylamide gel showing hard protein corona formation on FRT nanovehicles in fetal bovine serum (FBS). 10-250 kDa protein ladder (L), Elli without (1) and with formed hard corona (2), FRT-Elli without (3) and with formed hard corona (4), FRT-Elli-GASNGINAYLC without (5) and with formed hard corona (6), FRT-Elli-SLWERLAYGIC without (7) and with formed hard corona (8), FRT without (9) and with formed hard corona (10). c Hemolytic properties of free Elli, FRT-Elli, FRT-Elli-GASNGINAYLC and FRT-Elli-SLWERLAYGIC. d Nuclear DNA fragmentation analyzed by single-cell gel electrophoresis in off-target HBL-100 cells treated for 6 h with of 20 µM Elli in the form of free Elli, FRT-Elli, FRT-Elli-GASNGINAYLC and FRT-Elli-SLWERLAYGIC. Phosphate-buffered saline (PBS) and H2O2 were employed as negative and positive control, respectively