Fig. 2
From: Stem cell membrane-coated isotretinoin for acne treatment
Drug loading characters of STCM-ATRA-NPs. a Controlled release of ATRA from STCM-ATRA-NPs, followed daily at 37 °C in a hydroalcoholic solution, up to 7 days. b Penetration of ATRA and STCM-ATRA-NPs through the pig dermis, monitored over 8 h. Data shown are mean ± S.D., n = 3. Franz diffusion cell of c ATRA and d STCM-ATRA-NPs for 8 h at 37 °C and 100 rpm. STCM-ATRA-NPs at 8 h showed more uniform distribution and accumulation compared to ATRA