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Fig. 10 | Journal of Nanobiotechnology

Fig. 10

From: Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes

Fig. 10

Exosomal miR-124-3p suppressed the activation of M1 microglia through PI3K/AKT/NF-κB signaling cascades. a Representative images and quantification of western blots for PI3K/AKT/NF-κB signaling cascades in LPS-stimulated microglia when administrating miR-NCOE-Exos, miR-124-3pOE-Exos, miR-124-3pOE-Exos + vector and miR-124-3pOE-Exos + MYH9. b Representative images and quantification of western blots for PI3K/AKT/NF-κB signaling cascades in LPS-stimulated microglia when administrating miR-NCKD-Exos, miR-124-3pKD-Exos, miR-124-3pKD-Exos + shNC and miR-124-3pKD-Exos + shMYH9. *P < 0.05

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