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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes

Fig. 6

Neuron-derived exosomes suppressed the activation of M1 microglia and A1 astrocytes by delivering miR-124-3p in vitro. a The concentrations of pro-inflammatory cytokines in microglia in the miR-NCOE-Exos, miR-124-3pOE-Exos, miR-NCKD-Exos and miR-124-3pKD-Exos groups. b Representative immunostaining image of IBA1/INOS in the microglia and the analysis of INOS-positive microglia in each group. c Representative immunostaining image of GFAP/C3 in the astrocyte and the analysis of C3-positive astrocyte in each group. d The protein expression levels of M1-related genes were detected by western blot in microglia in the different groups. e The protein expression levels of A1-related genes were detected by western blot in astrocyte in the different groups. *P < 0.05 and #P < 0.05

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