Fig. 9

a Transverse and vertical 2-D images and 3-D reconstructed views (ROI, 200 µm from the implant surface) of the Micro-CT analysis to show the new bone formation around the Ti implants at 4 weeks. Scale bar: 15 mm on the 2-D images and 1 mm on the 3-D ones. b The bone volume per total volume (BV/TV), the mean trabecular thickness (Tb.Th), the mean trabecular number (Tb.N) and the mean trabecular separation (Tb.Sp) within the ROI zone. ^{@, @@, @@@}p < 0.05, 0.01 and 0.001 vs the PT surface *, ***p < 0.05 and 0.001 vs the naked MAO surface; ^#,###p < 0.05, and 0.001 vs the CS-coated MAO surface; ^&,&&,&&&p < 0.05, 0.01 and 0.001 vs the CS-antimiR-control/HA PEM-functionalized MAO surface