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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Synergistic co-delivery of diacid metabolite of norcantharidin and ABT-737 based on folate-modified lipid bilayer-coated mesoporous silica nanoparticle against hepatic carcinoma

Fig. 3

Evaluation of in vitro antineoplastic activity. a In vitro cytotoxicity of free drugs and nanoparticle samples on H22 cell lines for 24 h (n = 3). b, d Apoptotic effects of free drugs and nanoparticle samples in H22 cell lines (n = 3). c, e The mitochondrial activity was examined by JC-1 detection (n = 3). Notes: In vitro cytotoxicity study, the concentrations of DM-NCTD of DM-NCTD or DM-NCTD + ABT-737 group were 2.5, 5 and 10 μg/ml; the concentrations of ABT-737 of ABT-737 or DM-NCTD + ABT-737 group were 1.25, 2.5 and 5 μg/ml. The concentrations of nanoparticle groups were calculated according to the contents of DM-NCTD (2.5, 5 and 10 μg/ml). **P < 0.01, *P < 0.05 vs FA-LB(ABT-737)-(DM-NCTD@CHMSN) group; ##P < 0.01, #P < 0.05 vs LB(ABT-737)-(DM-NCTD@CHMSN) group

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