Fig. 5

a The penetrating ability of Cou-6-labeled NLCs into MDA-MB-231 tumor spheres (a: Cou-6-Sol, b: Cou-6-NLC, c: RGE-Cou-6-NLC, and d: R9dGR-Cou-6-NLC), scale bar = 200 μm. b The bio-distribution study of Dir-NLC in tumor bearing mice (a: Sal, b: Dir-Sol, c: Dir-NLC, d: RGE-Dir-NLC, and e: R9dGR-Dir-NLC). c Ex-vivo fluorescence images of the organs and tumor tissues excised from mice treated with different Dir formulations (a: Sal, b: Dir-Sol, c: Dir-NLC, d: RGE-Dir-NLC, and e: R9dGR-Dir-NLC). d The statistical results of fluorescence signal of tumor obtained from mice treated with different Dir formulations. *P < 0.05; **P < 0.01; ***P < 0.001. Results are expressed as mean ± SD