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Table 3 Pharmacokinetic parameters of PTX in different formulations

From: Dual drug-loaded nano-platform for targeted cancer therapy: toward clinical therapeutic efficacy of multifunctionality

Parameter

Units

PTX-Sol

Taxol

GA/PTX-NLC

RGE-GA/PTX-NLC

R9dGR-GA/PTX-NLC

AUC0→∞

μg/mL h

7.66 ± 0.79

22.58 ± 3.55**

16.66 ± 3.35**

17.65 ± 1.83**

13.53 ± 1.83*

t½

h

2.62 ± 0.20

2.16 ± 0.16

3.25 ± 0.45**

2.92 ± 0.03

3.48 ± 0.10**

CL

mL/h/kg

960.32 ± 100.05

328.26 ± 47.80***

451.69 ± 101.70***

416.52 ± 43.27***

546.34 ± 75.85***

MRT

h

1.88 ± 0.14

1.92 ± 0.04

2.23 ± 0.32

2.11 ± 0.02

2.43 ± 0.09*

  1. *P < 0.05, **P < 0.01, ***P < 0.001 compared with PTX-Sol. Results are expressed as mean ± SD (n = 3)
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Journal of Nanobiotechnology

ISSN: 1477-3155

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