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Table 4 Pharmacokinetic parameters of GA in different formulations

From: Dual drug-loaded nano-platform for targeted cancer therapy: toward clinical therapeutic efficacy of multifunctionality

Parameter

Units

GA-Sol

GA/PTX-NLC

RGE-GA/PTX-NLC

R9dGR-GA/PTX-NLC

AUC0→∞

μg/mL h

1.44 ± 0.23

2.56 ± 0.61

2.45 ± 0.57

3.10 ± 0.99*

t½

h

2.70 ± 0.68

5.12 ± 0.75**

4.72 ± 0.60**

4.38 ± 0.33*

CL

mL/h/kg

5647.32 ± 963.53

3248.17 ± 758.95**

3381.66 ± 772.54*

2754.72 ± 824.02**

MRT

h

3.29 ± 0.24

4.54 ± 0.24**

4.37 ± 0.44**

5.14 ± 0.52***

  1. *P < 0.05, **P < 0.01, ***P < 0.001 compared with GA-Sol. Results are expressed as mean ± SD (n = 3)
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Journal of Nanobiotechnology

ISSN: 1477-3155

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