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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: Multiparametric investigation of non functionalized-AGuIX nanoparticles in 3D human airway epithelium models demonstrates preferential targeting of tumor cells

Fig. 1

FCM quantification of AGuIX® uptake in MucilAir™ cultures indicated a weak uptake in ciliated and basal cells. Representative histograms from one of the 3 experiments involving (a) control cells and AGuIX®-FITC-exposed cells for (b) 24 and (c) 72 h. The percentage of FITC-positive cells is presented as the geometric mean fluorescence intensity (MFI). Representative dot-plots of CLCA1 versus AGuIX® signal at (d) 24 and (e) 72 h, with respectively 9% CLCA1-positive cells including 2% AGuIX®-positive versus 12% CLCA1-negative/AGuIX-positive cells and 10% CLCA1-positive cells including 2% AGuIX®-positive versus 9% CLCA1-negative/AGuIX-positive cells, and (f) the corresponding number of AGuIX®-positive cells expressed as % ± SD (mean of 3 experiments)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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