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Fig. 12 | Journal of Nanobiotechnology

Fig. 12

From: Radiosensitizing high-Z metal nanoparticles for enhanced radiotherapy of glioblastoma multiforme

Fig. 12

(Reproduced with permission from reference: [126], copyright 2013 Springer Nature)

UCA-RGD for CT imaging-guided radiotherapy with effective radiosensitization. a TEM characterization of RGD-labelled UCA in water. Scale bar is 100 nm. b CT images of UCA and Iobitridol with various concentration. c Confocal images of upconversion luminescence (UCL) with UCA-RGD and UCA for 1-h incubation at 800 μg Yb/mL. The two lines above are conducted with U87MG cells and the two lines below are conducted with MCF-7 cells. d In vivo transverse slices and 3D volume rendering CT images for U87MG tumor-bearing mice. The comparison includes UCA-RGD (targeted group) or UCA (non-targeted group). e CT values of tumor which coincide with (d). f, g Tumor growth inhibition following several types of compare and contrast treatment (Control, RT alone, RT&UCA, RT&UCA-RGB). BaYbF5:2% Er3+ nanocube (UCA) conjugated with arginine-glycine-aspartic acid (RGD) peptides (UCA-RGD)

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