Fig. 8
From: Radiosensitizing high-Z metal nanoparticles for enhanced radiotherapy of glioblastoma multiforme
(Reproduced with permission from reference: [103], copyright 2011 American Chemical Society)
The survival improvement of brain tumor bearing rats with combination of GBN and MRT. a HR-TEM image of encapsulated gadolinium oxide NPs in polysiloxane shell. Scale bar is 2 nm. b The enhancement of gadolinium with proportion to concentration as the contrast. Upper: T1-weighted, bottom: SPCT. c Brain images of 9LGS-bearing rat by T1-weighted at various time points. d MRI signal in tumor (purple) and in normal tissue of equivalent surface (blue) in process of time. e Survival cureve of 9LGS-bearing rate. Black dash curve represents without treatment group (n = 4). Blue curve, red curve and green curve represent only treated by MRT (n = 7), treated by MRT 5 min (n = 8) and 20 min (n = 8), respectively. The survival curve was filled out up to 103 days after tumor implantation. MRT: microbeam radiation therapy