Fig. 9
From: Radiosensitizing high-Z metal nanoparticles for enhanced radiotherapy of glioblastoma multiforme
(Reproduced with permission from reference: [114], copyright 2013 Royal Society of Chemistry)
Radiation enhancement effects of PVP-coated AgNP. a TEM characterization of silver NPs. Scale bar is 50 nm. b Kaplan–Meier survival curve for C6 glioma-bearing rats with intratumoral administration of AgNPs. Six groups were involved as comparison: untreated animals (x); 10 μg of AgNPs alone (white triangle); 20 μg of AgNPs alone (white diamond); irradiated control (black down-pointing triangle); 10 μg of AgNPs + 10 Gy (white triangle); and 20 μg of AgNPs + 10 Gy (black up-pointing triangle). c Proliferating cell nuclear antigen (PCNA) or terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick and labeling (TUNEL) staining of each comparison group. d Proliferation and apoptosis were quantitatively analysed into vertical bar charts, individually. e The brain images of glioma-bearing. (i) and (ii) represent frontal slices of untreated control in extremis and rat surviving for 200 days. (iii) and (iv) represent T2-weighted MR images of well-implanted tumor after 7 days and rat surviving for 200 days which exhibits absence of tumor, respectively