Fig. 5From: Internal cross-linked polymeric nanoparticles with dual sensitivity for combination therapy of muscle-invasive bladder cancerEstablishment of an orthotopic bladder cancer model in C57BL/6 mice and in vivo distribution of free IR780 and DOX&IR780@PEG-PCL-SS NPs. a The upper is the biodistribution of NPs in normal mouse. The below is the In vivo distribution of free IR780 and DOX&IR780@PEG-PCL-SS NPs in cancer mice. The right size is ex vivo imaging of NPs in lung, heart, liver, spleen, kidney and bladder of the mice. b Through small animal CT, a tumor is shown when the bladder of the mouse is filled with urine 7Â days after MB49-luciferase cells inject into the bladder wallBack to article page