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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Dual-responsive doxorubicin-loaded nanomicelles for enhanced cancer therapy

Fig. 2

a Illustration of the preparation procedure and pH/ROS-dual sensitivity of PPT/D(DMA)@DOX. The micelle took out DMA at pH 6.8 to expose the positive charges, and the release of DOX was triggered quickly by the ROS below pH 6.8. b The zeta potential PPT/D(DMA) and PPT/D(SA) after incubation at pH 5.5, 6.8 and 7.4 for 200 min. c The zeta potential PPT/D(DMA)@DOX and PPT/D(SA)@DOX after incubation at pH 5.5, 6.8 and 7.4 for 200 min. d Diameter of PPT/D(DMA) and PPT/D(SA) after incubation at pH 5.5, 6.8 and 7.4 for 200 min. e Diameter of PPT/D(DMA)@DOX and PPT/D(SA)@DOX after incubation at pH pH 5.5, 6.8 and 7.4 for 200 min. f Cumulative release of DOX from PPT/D(DMA)@DOX and PPT/D(SA)@DOX micelles at pH 5.5, 6.8 and 7.4. g Cumulative release of TOS from PPT/D(DMA)@DOX micelles at pH 5.5, 6.8 and 7.4. h Cumulative release of DOX from PPT/D(DMA)@DOX and PPT/D(SA)@DOX micelles at pH 7.4 after treatment with H2O2 (100 nM,10 μM,100 μM and 10 mM). i Cumulative release of DOX from mPEG-PLGA micelles at pH 6.8 after treatment with 0.1 or 10 mM of H2O2

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