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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Micelles self-assembled by 3-O-β-d-glucopyranosyl latycodigenin enhance cell membrane permeability, promote antibiotic pulmonary targeting and improve anti-infective efficacy

Fig. 6

GP-682 micelles improved the antibacterial effect. a Immunofluorescence images of PA 14 strains distributed in the mouse lung. The scale bar represents 250 μm (left panel); the histogram presents the relative fluorescence of PA 14 strains (right panel) (n = 3). GP-682 micelles enhanced the anti-inflammatory effect of Lev and inhibited the production of TNF-α (b), IL-6 (c) and IL-8 (d) induced by acute infection with PA 14 strains (n = 6). (Bars represent mean ± SD, Con: control group; Mod: model group; Lev: Lev group; GP-682 micelles: GP-682 micelles group; GP-682 micelles + Lev: combined GP-682 micelles and Lev group. **p < 0.01, ***p < 0.001 compared to the Mod group; ###p < 0.001 compared to the Con group; ∆p < 0.05, ∆∆p < 0.01, ∆∆∆p < 0.001 compared to the Lev group)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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