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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Alpha lipoic acid antagonizes cytotoxicity of cobalt nanoparticles by inhibiting ferroptosis-like cell death

Fig. 5

Spectrophotometric measurement of intracellular reduced and oxidized GSH in Balb/3T3 cells. The cells were exposed to CoNPs (400 μM) and ALA (200 μM) for 24 h. The administration of CoNPs led to a reduction of the levels of T-GSH, GSH, and GSH/GSSG ratio, as well as the elevation of the GSSG level. Importantly, all the CoNPs-induced effects were alleviated by ALA significantly for the co-treatment group. All the data were expressed as mean ± SD of three independent experiments performed in triplicates. *p < 0.01, #p < 0.05 vs. control

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