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Table 2 Relevant studies focusing on liposomes for oxidative stress

From: Novel drug delivery systems targeting oxidative stress in chronic obstructive pulmonary disease: a review

Nanocarrier composition Drug Method of preparation Size Route of administration Mode of action Ref
DPPC, cholesterol and stearylamine CAT or SOD Reverse-phase evaporation Intravenous Decrease lipid peroxidation products (malondialdehyde, conjugated dienes, lipid hydroperoxides) [93]
DPPC a-Tocopherol Reverse-phase evaporation 320 ± 40 nm Intratracheal Reduce myeloperoxidase activity and reverse of phorbol myristate acetate-induced changes in lung edema, lipid peroxidation, enzyme and alkaline phosphatase activities [94]
DPPC and cholesterol Cu, Zn SOD and CAT Reverse-phase evaporation 200 nm Intratracheal, instillation Increase antioxidant activity of alveolar type II cell, increase lung antioxidant enzyme levels [95, 96]
DPPC SOD and/or CAT Reverse-phase evaporation 0.1–0.4 μm Intratracheal Prevent the chronic vascular and parenchymal damage due to oxygen toxicity [97]
DPPC NAC Reverse-phase evaporation - Intratracheal Increase pulmonary glutathione [98]
DPPC NAC, glutathione, a-tocopherol Thin-film hydration method 100 nm Intratracheal instillation Reduce CINC-1, IL-1β, and TNF-α [99]
Phospholipid and cholesterol NAC Reverse phase evaporation and spray drying 100 nm Inhalation Against TBARS production [100]
DPPC a-Tocopherol Solvent evaporation method - Intraperitoneal, injection Reduce acute inflammatory, cell influx and suppress collagen formation in lung tissue [101]
Chitosan, hyaluronan, and phospholipids Curcumin Sonication, stirring 130 nm A549 cells Cell relative metabolic activity ≥ 80% after treated with hydrogen peroxide [102]
  1. DPPC: L-a-dipalmitoylphosphatidyl-choline; NAC: N-acetylcysteine; TBARS: thiobarbituric acid reactive species