Fig. 6
The C-EVs improve the therapeutic effect of HUCMSCs on articular cartilage repair in the rabbit model. a Gross morphology of repaired cartilage of the control group, The C-EVs group, and the TGF-β group at 4 weeks and 12 weeks post-surgery. b Macroscopic scores of regenerative tissues from the control group, the C-EVs group, and the TGF-β group. n = 12. ***p < 0.001. c H&E staining of repaired cartilage from the control group, the C-EVs group, and the TGF-β group. d Safranin O-fast green staining of repaired cartilage from the control group, the C-EVs group, and the TGF-β group. e Immunohistochemical staining of collagen type II in repaired cartilage from the control group, the C-EVs group, and the TGF-β group. f Histological scores of regenerative tissues from each group. n = 12. ***p < 0.001