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Table 2 Hydrodynamic diameter and SD, ζ-potential and DL of PEGylated proteinoid NPs

From: Designed proteinoid polymers and nanoparticles encapsulating risperidone for enhanced antipsychotic activity

Proteinoid NPs Diameter (nm) ζ-potential (mV) DL (w/w%)
Prot.1 78 ± 4 12 ± 3
Prot.2 58 ± 2 − 10 ± 4
Prot.3 94 ± 7 12 ± 1
Prot.4 90 ± 4 − 8 ± 2
Prot.1/RSP 97 ± 2 13 ± 3 20 ± 0.1
Prot.2/RSP 86 ± 3 − 16 ± 1 20 ± 0.1
Prot.3/RSP 120 ± 5 13 ± 3 19 ± 0.4
Prot.4/RSP 122 ± 6 − 12 ± 2 19 ± 0.3
  1. Proteinoid particles were formed by a self-assembly process in aqueous 10 µM NaCl solution containing 1% DMSO. The initial RSP concentration was 20% w/w relative to the proteinoid. The hollow proteinoids and Prot./RSP NPs were PEGylated. The hydrodynamic diameter was measured by DLS, the ζ-potential was measured at pH = 7.4 by a ζ-potential analyzer, and the DL was measured by HPLC using a calibration curve of standard RSP solutions