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Table 2 Hydrodynamic diameter and SD, ζ-potential and DL of PEGylated proteinoid NPs

From: Designed proteinoid polymers and nanoparticles encapsulating risperidone for enhanced antipsychotic activity

Proteinoid NPs

Diameter (nm)

ζ-potential (mV)

DL (w/w%)

Prot.1

78 ± 4

12 ± 3

–

Prot.2

58 ± 2

− 10 ± 4

–

Prot.3

94 ± 7

12 ± 1

–

Prot.4

90 ± 4

− 8 ± 2

–

Prot.1/RSP

97 ± 2

13 ± 3

20 ± 0.1

Prot.2/RSP

86 ± 3

− 16 ± 1

20 ± 0.1

Prot.3/RSP

120 ± 5

13 ± 3

19 ± 0.4

Prot.4/RSP

122 ± 6

− 12 ± 2

19 ± 0.3

  1. Proteinoid particles were formed by a self-assembly process in aqueous 10 µM NaCl solution containing 1% DMSO. The initial RSP concentration was 20% w/w relative to the proteinoid. The hollow proteinoids and Prot./RSP NPs were PEGylated. The hydrodynamic diameter was measured by DLS, the ζ-potential was measured at pH = 7.4 by a ζ-potential analyzer, and the DL was measured by HPLC using a calibration curve of standard RSP solutions