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Table 3 Hydrodynamic diameter and SD, ζ-potential and DL of Prot.1,2/RSP NPs loaded with various concentrations of RSP

From: Designed proteinoid polymers and nanoparticles encapsulating risperidone for enhanced antipsychotic activity

Prot./RSP (%)

Diameter (nm)

ζ-potential (mV)

DL (w/w%)

Prot.1/RSP (10%)

68 ± 2

12 ± 1

10 ± 0.1

Prot.1/RSP (20%)

97 ± 4

13 ± 3

20 ± 0.1

Prot.1/RSP (30%)

143 ± 5

17 ± 2

30 ± 0.1

Prot.1/RSP (40%)

178 ± 8

18 ± 2

40 ± 0.3

Prot.1/RSP (50%)

215 ± 7

19 ± 3

50 ± 0.2

Prot.2/RSP (10%)

68 ± 2

− 10 ± 2

10 ± 0.1

Prot.2/RSP (20%)

86 ± 3

− 16 ± 1

20 ± 0.1

Prot.2/RSP (30%)

136 ± 5

− 16 ± 2

30 ± 0.3

Prot.2/RSP (40%)

156 ± 8

− 17 ± 1

40 ± 0.2

Prot.2/RSP (50%)

194 ± 9

− 19 ± 3

50 ± 0.4

  1. Proteinoid particles were formed by a self-assembly process in 10 µM NaCl aqueous solution containing 1% DMSO. The initial RSP concentration was between 10 and 50% w/w relative to the proteinoid. The hydrodynamic diameter was measured by DLS, the ζ-potential was measured at pH = 7.4 by a ζ-potential analyzer, and the DL was measured by HPLC using a calibration curve with standard RSP solutions