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Table 3 Hydrodynamic diameter and SD, ζ-potential and DL of Prot.1,2/RSP NPs loaded with various concentrations of RSP

From: Designed proteinoid polymers and nanoparticles encapsulating risperidone for enhanced antipsychotic activity

Prot./RSP (%) Diameter (nm) ζ-potential (mV) DL (w/w%)
Prot.1/RSP (10%) 68 ± 2 12 ± 1 10 ± 0.1
Prot.1/RSP (20%) 97 ± 4 13 ± 3 20 ± 0.1
Prot.1/RSP (30%) 143 ± 5 17 ± 2 30 ± 0.1
Prot.1/RSP (40%) 178 ± 8 18 ± 2 40 ± 0.3
Prot.1/RSP (50%) 215 ± 7 19 ± 3 50 ± 0.2
Prot.2/RSP (10%) 68 ± 2 − 10 ± 2 10 ± 0.1
Prot.2/RSP (20%) 86 ± 3 − 16 ± 1 20 ± 0.1
Prot.2/RSP (30%) 136 ± 5 − 16 ± 2 30 ± 0.3
Prot.2/RSP (40%) 156 ± 8 − 17 ± 1 40 ± 0.2
Prot.2/RSP (50%) 194 ± 9 − 19 ± 3 50 ± 0.4
  1. Proteinoid particles were formed by a self-assembly process in 10 µM NaCl aqueous solution containing 1% DMSO. The initial RSP concentration was between 10 and 50% w/w relative to the proteinoid. The hydrodynamic diameter was measured by DLS, the ζ-potential was measured at pH = 7.4 by a ζ-potential analyzer, and the DL was measured by HPLC using a calibration curve with standard RSP solutions