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Fig. 10 | Journal of Nanobiotechnology

Fig. 10

From: Exosomal PD-L1 and N-cadherin predict pulmonary metastasis progression for osteosarcoma patients

Fig. 10

Schematic diagram showed the outline of osteosarcoma pulmonary metastasis process in which osteosarcoma-derived exosomes involved. Osteosarcoma released its exosomes into the microenvironment and osteosarcoma-derived exosomes carried PD-L1 and N-cadherin to the lung through the circulatory system. Osteosarcoma cells at the metastatic lesions of lung internalized exosomes transmitted from the primary osteosarcoma and these exosomes assisted the migration and progression of metastatic tumors. Detection of exosomal PD-L1 and N-cadherin levels in the circulatory system could probably predict the occurrence of osteosarcoma pulmonary metastasis

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