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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Exosomal PD-L1 and N-cadherin predict pulmonary metastasis progression for osteosarcoma patients

Fig. 6

Effect of exosome secretion inhibitor GW4869 on the progression of osteosarcoma pulmonary metastasis. a Nanoparticle tracking analysis showing inhibition of 143B exosome secretion by utilizating GW4869; b The flowchart showing the plan to test GW4869 on pulmonary metastasis nodules and metastatic lesion area in vivo; c Gross specimens of lungs in three groups; d Weight change of mice in three groups; e Haematoxylin and eosin staining to show the metastatic lesions in the lung of three groups; fh Maximum diameter, number and areas of metastatic lesion nodules in three groups; ik Upregulation of E-cadherin and downregulation of N-cadherin were observed in the metastatic lesion treated by GW4869; l, m Suppression of PD-L1 expression at the pulmonary metastatic lesions by administration of GW4869 and upregulation by the treatment of exosomes from 143B cells. Experiments were performed using 5 mice for each group. Data represent mean ± SD

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