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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: Exosomes containing miRNAs targeting HER2 synthesis and engineered to adhere to HER2 on tumor cells surface exhibit enhanced antitumor activity

Fig. 1

Downregulation of HER2 by miR-HER2-E1 and miR-HER2-E4 in SK-OV-3 and HEp-2 cells. a Immunoblotting analysis of HER2 protein levels of SK-OV-3 cells transfected with 0.5 μg of plasmids expressing miR-HER2-E1, miR-HER2-E4 or nontargeting (NT) miRNA. b The band densities of HER2 normalized to GAPDH indicating relative HER2/GAPDH expressing in SK-OV-3 cells were quantified and are presented as the mean ± standard deviation from three independent experiments. c HEp-2 cells were cotransfected with 0.5 μg of plasmid expressing miR-HER2-E1, miR-HER2-E4 or the NT miRNA and 0.2 μg of plasmid encoding His-tagged HER2. GAPDH served as a loading control. d The band densities of HER2 normalized to GAPDH indicating relative HER2/GAPDH expressing in HEp-2 cells were quantified and are presented as the mean ± standard deviation from three independent experiments. *p < 0.05

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Journal of Nanobiotechnology

ISSN: 1477-3155

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