Fig. 7
Antitumor efficacy of exosomes adhering to HER2 and expressing miR-HER2-E1. BALB/c-derived nude mice implanted with SK-OV-3 tumors with an average volume of 80 mm3 were injected intravenously with exosomes purified from the parental HEK-293 cell line (293), the miR-HER2-E1-expressing stable cell line (293-miR-XS) or the stable cell line with coexpression of the HER2 protein ligand and miR-HER2-E1 (293-miR-XS-HER2). Exosomes were injected 3 μg/animal (a) or 30 μg/animal (b) every three days, for a total of 8 injections (indicated by arrow). The tumor size was measured every three days. The results are shown as mean tumor volume (mm3) ± standard deviation (n = 6). * and *** represent p < 0.05 and p < 0.001 compared with the 293-miR-XS group