Fig. 1
Exosomes derived from MSCs pretreated with MIF alleviated Dox-induced cardiac injury. a The schema of the mice treatment. b Representative images of echocardiography exhibiting changes in cardiac function in each group. Echocardiographic analysis of ejection fraction (EF) c and fractional shortening (FS) d in week 2 after the first cycle of Dox, Dox + exosome, Dox + exosomeMIF, or control treatment. e–j The expression of senescence-related genes p27 (E), p16 (f), and p21 (g), and rejuvenation-related genes Sirt1 (h), Sirt2 (i), and Sirt6 (j) in the aforementioned groups was examined using qRT-PCR. Each column represents the mean ± SD of three independent experiments. *P < 0.05 versus Control; ▲P < 0.05 versus Dox; ○P < 0.05 versus Dox + exosome in one-way analysis of variance, n = 3