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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Exosomal LncRNA–NEAT1 derived from MIF-treated mesenchymal stem cells protected against doxorubicin-induced cardiac senescence through sponging miR-221-3p

Fig. 3

ExosomeMIF treatment reduced Dox-related cardiac injury through inhibiting miR-221-3p. a MiR-221-3p expression was validated by qRT-PCR in cardiac tissue. *P < 0.05 versus Control; P < 0.05 versus Dox; P < 0.05 versus Dox + exosomeMIF+siRNA−LncRNA−NEAT1 in one-way analysis of variance, n = 3. b Overexpression effect was validated by qRT-PCR. *P < 0.05 versus miR-221-3p mimic in one-way analysis of variance, n = 3. c Representative images of echocardiography exhibiting changes in cardiac function in each group. Echocardiographic analysis of EF (d) and FS (e) in week 2 after treatment. f, g p27 and p16 mRNA levels were analyzed using qRT-PCR. h Representative images of SA-β-gal staining. i Percentage of β-gal-positive cells. Each column represents the mean ± SD of three independent experiments. *P < 0.05 vs Control; P < 0.05 versus Dox; P < 0.05 versus Dox + exosomeMIF + miR-221-3p mimic in one-way analysis of variance, n = 3

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