Fig. 7

HK2 knockdown induced by DFPP-shHK2 improved the cisplatin sensitivity of ovarian cancer cells. a Cell viability in A2780 and A2780CP cells treated with DFPP-shHK2 combined with cisplatin. The concentration of cisplatin ranged from 0.5 μg/ml to 20 μg/ml. DFPP-shHK2 was used at a plasmid-equivalent concentration of 1.0 μg/ml. b Cell apoptosis according to flow cytometry in A2780 and A2780CP cells treated with DFPP-shHK2 and cisplatin alone or in combination. The concentration of cisplatin was 2.5 μg/ml. c The expression levels of cisplatin resistance-associated proteins according to western blotting in A2780CP cells treated with DFPP-shHK2 and cisplatin alone or in combination for 48 h. *P < 0.05, **P < 0.01 vs. control