Fig. 9

In vivo toxicity of HK2 shRNA-loaded nanoparticles. Nude mice bearing cisplatin-sensitive A2780 tumor xenografts received an intravenous administration of saline, PP-shHK2, FPP-shHK2 or DFPP-shHK2 on days 1, 4, 7 and 10. a Body weight changes of the mice. The blood levels of ALT (b), Cr (c) and BUN (d) in all mice. e HE staining of the liver, kidney, spleen and lung (200X)