Fig. 2

In vivo targeting ability of DEX-PS to tumor and acute peritonitis. a Typical in vivo images illustrating Nile Red fluorescence signals in tumor-bearing mice. b Ex vivo images illustrating Nile Red fluorescence signals in isolated tumors. c Distribution of nanoparticles in tumor section observed by confocal laser-scanning microscopy. d Colocalization analysis of nanoparticles with iNOS and CD163. e Pearson correlation assay of nanoparticles and CD163. f Pearson correlation assay of nanoparticles and iNOS. g Typical in vivo distribution of Nile Red fluorescent signals in acute peritonitis. The area marked by the dotted black line is the focus of disease, while the area marked by the solid yellow line is the region of interest. COOH-PS, carboxyl-functionalized polystyrene; DEX-PS: dextran-functionalized polystyrene; iNOS: inducible nitric oxide synthase; PS: polystyrene