Skip to main content
Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: The double-edged sword effect of macrophage targeting delivery system in different macrophage subsets related diseases

Fig. 6

The effect of DEX-PS on progression of macrophage-related diseases. Typical cytokine expression (a, b) in abdominal dropsy and survival rate (c) of mice administered various NPs after peritonitis induced by i.p. injection of zymosan (n = 10). Typical cytokine expression (d) in abdominal dropsy and survival rate (e) of mice administered various NPs after peritonitis induced by i.p. injection of acetic acid (n = 5). f Schematic of macrophage-tumor cell co-culture system. g Proportion of apoptotic 4T1 tumor cells in the co-culture system determined by TUNEL assay (n = 3). h Viability of 4T1 tumor cells in various co-culture systems (n = 3). i Typical cytokine expression in tumors isolated from 4T1-bearing mice treated with various NPs (n = 6). j Typical immunofluorescence images of tumors isolated from 4T-bearing mice treated with various NPs. k Quantification analysis of fluorescence intensity of each cell (n = 3). * In a, c, i and k indicates p < 0.05, vs. saline. Data are presented as the mean ± SD, * In g and h indicates p < 0.05. Scale bar indicates 100 µm. COOH-PS: carboxyl-functionalized polystyrene; DEX-PS: dextran-functionalized polystyrene; IL-1β: interleukin 1 beta; IL-10: interleukin 10; iNOS: inducible nitric oxide synthase; PS: polystyrene; TGF-β: transforming growth factor beta; TNF-α: tumor necrosis factor alpha

Back to article page