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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease

Fig. 4

W20/XD4-SPIONs reduced neuroinflammation and oxidative stress in the brains of AD mice. GFAP immunostaining (a) and Iba-1 immunostaining (b) in the brains of AD mice treated with various SPIONs. Scale bar 250 μm. Quantification of GFAP (c) and Iba-1 (d) immunostaining. The levels of IL-1β (e), IL-6 (f), and TNF-α (g) in the brain lysates of AD mice and their WT littermates treated with various SPIONs were determined using corresponding ELISA kits. The levels of GSH (h), GSSG (i), GSH/GSSG ratio (j) and ROS (k) in the brain lysates of AD mice and their WT littermates treated with various SPIONs were determined using corresponding commercial kits. n = 8 mice/group. Data represent means ± SEM and were analyzed by one-way ANOVA with Tukey’s test. *P < 0.05, **P < 0.01, ***P < 0.001

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